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Detection of an endogenous inhibitor of benzodiazepine receptor binding

Korneev, A.Ia.; Faktor, M.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 96(7): 64-65

1983

ISSN/ISBN: 0365-9615
PMID: 6307424
Document Number: 214338
An original 1-stage method for isolating from brain tissue a water-soluble fraction containing an inhibitor of benzodiazepine specific binding is suggested, and the properties of the inhibitor are described. The inhibitor is a thermostable compound with a MW of 2000 to 10,000 daltons. It inhibits diazepam binding depending on the concentration. The IC50 for diazepam binding is .apprx. 10-fold less than the inhibitor concentration in the brain tissue. The inhibitor is distributed heterogeneously in the rat brain (the maximal content in the cerebellum and cortex) and bovine brain (the maximal content in the thalamus and caudate nucleus).

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