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Neurotropic activity of lambertian acid and its amino derivatives

Tolstikova, T.G.; Voevoda, T.V.; Dolgikh, M.P.; Sorokina, I.V.

Eksperimental'naia i Klinicheskaia Farmakologiia 65(2): 9-11

2002

ISSN/ISBN: 0869-2092
PMID: 12109303
Document Number: 541745
The neurotropic activity of the originally synthesized methyl lambertianate (II), as well as lambertianic acid (I) and three amino derivatives (III - V) was studied. All compounds exhibit equally low toxicity, but differ in the type of influence upon CNS. The most pronounced action was observed for esters II and V. Compound II exhibited a strong antidepressant effect with stimulating action. Introduction of the amino group led to an opposite tendency: compound V exhibited an antipsychotic and sedative (calming) effect upon CNS, without any anticonvulsant action.

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