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N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship

Alexeeva, I.; Palchikovskaya, L.; Shalamay, A.; Nosach, L.; Zhovnovataya, V.; Povnitsa, O.; Dyachenko, N.

Acta Biochimica Polonica 47(1): 95-101

2000

ISSN/ISBN: 0001-527X
PMID: 10961682
Document Number: 520912
Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.

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