Aromatic N-mustard compounds. 1. Derivatives of 3-N, N-bis- (2-chlorethyl) amino-4-methylbenzoid acid
Cambanis, A.; Gericke, D.
Arzneimittel-Forschung 25(1): 1-9
1975
ISSN/ISBN: 0004-4172 PMID: 1173761 Document Number: 84268
Twenty-seven new derivatives of the 3-N,N-bis-(2-chlorethyl)-amino-4-methyl-benzoic-acid were synthesized and pharmacologically examined. The compounds showed to be highly active in the in vitro-vivo screening models (Crocker sarcoma 180, Sa-180; Friend virus leukemia, FVL) but less active in the in vivo screening models (leukemia L-1210; L-1210; Nemeth-Kellner lympho-sarcoma, NKL). The in vivo tumor growth inhibitions show that this class of compounds has possibilities for further improvement.