Effect of a limitation of the food ration on macrophage functional activity and angiogenesis in mice with metastasizing tumors
Sopotsinskaia, E.B.; Umanskiĭ, V.I.; Lisniak, I.A.
Voprosy Pitaniia 6: 48-50
1988
ISSN/ISBN: 0042-8833 PMID: 2466374 Document Number: 316283
In mice with metastasizing tumors that received a reduced (by 30-40%) daily ration, suppression of neovascularization processes and normalization of macrophage function were recorded: activity of macrophages in the area of the metastatic growth increased, while activity of macrophages suppressing T-lymphocytes in the spleen was decreased. It has been suggested that these effects play a role in the phenomenon observed by the authors--suppression of the metastatic processes in the test mice kept on a reduced food ration.