Effect of a food ration with a low-protein content on the processes of liver parenchyma recovery in rats after tetrachloromethane damage
Shorina, G.N.; Bgatova, N.P.; Simek, J.; Cervinková, Z.; Holecek, M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 105(3): 336-338
1988
ISSN/ISBN: 0365-9615 PMID: 3349175 Document Number: 310269
Male Wistar rats weighing 190-200 g were fed a low protein diet. Atrophy of cytoplasm was observed after a 3-week malnutrition. In early periods of liver regeneration (6 hr after CCl4 poisoning), an increase in DNA synthesis was accompanied by an increase in summary concentration of organelle membranes. Though their ploidy was higher than in the control, volume of hepatocytes and summary area of organelles surface membrane was smaller than in standard diet. These data show a reduced capacity for realization of genetic program during the regeneration period in protein-deficient rats.