Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats
Singh, J.; Garg, K.N.; Mehrotra, G.C.
Indian Journal of Experimental Biology 28(12): 1180-1183
1990
ISSN/ISBN: 0019-5189 PMID: 2099335 Document Number: 355690
Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (.gamma.-GT) and by histopathological observations of liver sections. Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and .gamma.-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in aspartate and glutamate pretreated animals as observed macroscopically and histologically.