Liver and serum N-acetyl-beta-D-glucosaminidase isoenzymes of normal rats and rats with acute carbon tetrachloride poisoning
Loginov, A.S.; Privalenko, M.N.; Belokopytova, M.V.
Voprosy Meditsinskoi Khimii 26(6): 800-802
1980
ISSN/ISBN: 0042-8809 PMID: 7456410 Document Number: 166682
Isoenzyme B of N-acetyl- beta-D-glucosaminidase prevailed in rat blood serum, while the A form of the enzyme dominated in liver tissue as shown by DEAE cellulose chromatography. The serum isoenzyme A was distinct from the corresponding tissue type in chromatographic properties. In acute intoxication of liver tissue with CCl4 the tissue isoenzyme A, characteristic for the liver tissue of intact animals, was found in blood serum. Occurrence of the tissue isoenzyme A in blood serum might reflect the pathological state of the tissue; an increase in content of the enzyme in blood plasma appears to develop due to liberation of the enzyme from tissues.