M1 and M2 macrophage phenotypes functional activity as essential components in innate immune response assessment
Liamina, S.V.; Vedenikin, T.I.; Borodovitsyna, O.A.; Kruglov, S.V.; Malyshev, I.I.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 98(8): 1030-1035
2012
ISSN/ISBN: 0869-8139 PMID: 23155628 Document Number: 656691
Macrophage capacity to phagocytosis and migration activity are crucial components in innate immune response assessment. Differences in functional responses of two macrophage phenotypes were detected. Phagocytic activity of proinflammatory alveolar M1 phenotype in relation to S. aureus is more expressed than of antinflammatory M2 phenotype. Comparative analysis of migration activity showed alternative dependence of migration index on the type of used chemoattractant.