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Effect of photodynamic therapy on tumor angiogenesis and metastasis in mice bearing Lewis lung carcinoma

Lisnjak, I.O.; Kutsenok, V.V.; Polyschuk, L.Z.; Gorobets, O.B.; Gamaleia, N.F.

Experimental Oncology 27(4): 333-335

2005

ISSN/ISBN: 1812-9269
PMID: 16404357
Document Number: 589579
To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis. The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Bl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA. It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue. The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue.

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