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Enzymatic Synthesis of Acidic β-Lactams (Review)

Sklyarenko, A.V.; EI'darov, M.A.; Kurochkina, V.B.; Yarotskii, S.V.

Prikladnaia Biokhimiia i Mikrobiologiia 51(6): 546-560

2015

ISSN/ISBN: 0555-1099
PMID: 26859956
Document Number: 684567
The currently known methods of enzymatic β-lactam synthesis, as well as the enzymes and heterogeneous biocatalysts used for this purpose, are presented, and the published reports on advances in the field of enzymatic synthesis of selected antibiotics belonging to the groups of acidic penicillins and acidic cephalosporins are summarized in the present review. The key conditions and parameters of biocatalytic processes, such as the biocatalyst form, concentration of the precursor compounds, solvent type, pH, temperature, etc. are analyzed and compared, and guidelines for further optimization of β-lactam synthesis are given. The present review may be of use for a wide range of readers, as well as to enzymology and biotechnology experts.

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