Synthesis, pro-apoptotic activity and 2D-QSAR studies of new analogues of fluphenazine
Zyta, J.; Jaszczyszyn, A.; Swiatek, P.; Gasiorowski, K.; Malinka, W.ła.
Acta Poloniae Pharmaceutica 71(1): 49-58
2014
ISSN/ISBN: 0001-6837 PMID: 24779194 Document Number: 672838
A series of 10 novel analogues of fluphenazine (FPh) were synthesized. Influence of the synthesized analogues of FPh on frequency of apoptosis and necrosis in cultures of human lymphocytes genotoxically damaged in vitro with benzoP-damaged cell cultures. Several statistically significant QSAR models were generated. Information obtained from 2D-QSAR study will be used in further design of analogues of FPh more active in cancer chemoprevention.
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