Receptor binding potencies of chlorpromazine, trifluoperazine, fluphenazine and their 10-N-substituted analogues
Savelyeva, M.V.; Baldenkov, G.N.; Kaverina, N.V.
Biomedica Biochimica Acta 47(12): 1085-1087
1988
ISSN/ISBN: 0232-766X PMID: 2855395 Document Number: 325143
Receptor interactions of three pairs of phenothiazine derivatives, namely chloropromazine, trifluoperazine, fluphenazine and their dialkylaminoacyl analogues were investigated. The data indicate that neuroleptic derivatives are less effective at dopamine (D2), alpha 1-adrenoceptors (AR) and histamine receptors (H1). No differences in affinity to alpha2-AR were observed. The chloropromazine analogue was more effective at muscarinic receptors of both types.