Effect of chlorpromazine on the relation between temperature and the binding of ANS by human erythrocytes
Chernitskiĭ, E.A.; Vorobeĭ, A.V.; Konev, S.V.
Biofizika 23(1): 163-164
1978
ISSN/ISBN: 0006-3029 PMID: 623813 Document Number: 129252
It has been shown that under the effect of chlorpromazin (concentration to 2.10(-5) M) breaks observed on Arrhenius graphs of the rate constant of ANS binding with erythrocytes (k) at 28 and 36 degrees C are shifted to the region of low temperatures approximately to a similar interval (14-15 degrees C). The value k measured at 22 degrees C is not changed within the pH range of 5-7. It is concluded that breaks characterised the initial and final stages of temperature transition initiated in the zone of acid phospholipid of membranes.