Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal
Ramkumar, V.; el-Fakahany, E.E.
Research Communications in Chemical Pathology and Pharmacology 48(3): 463-466
1985
ISSN/ISBN: 0034-5164 PMID: 4040645 Document Number: 243103
Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.