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Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid

Atwell, G.J.; Rewcastle, G.W.; Baguley, B.C.; Denny, W.A.

Anti-Cancer Drug Design 4(2): 161-169

1989

ISSN/ISBN: 0266-9536
PMID: 2803464
Document Number: 762
A number of structural analogues of the solid tumor active drug flavone-acetic acid have been prepared and evaluated for in vivo activity against colon 38 adenocarcinoma, in order to extend the limited structure-activity relationships available for compounds with this type of activity. Apart from the fused ring analogue xanthenone-4-acetic acid, structural and electronic modifications of the nucleus led to inactive compounds, suggesting the existence of quite narrow structure-activity relationships.

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Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid

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