Synthesis and beta-adrenoceptor blocking activity of thiophenic analogues of metoprolol

Conde, S.; Corral, C.; Lissavetzky; Darias, V.; Martin, D.

Il Farmaco; Edizione Scientifica 41(1): 80-88

1986


ISSN/ISBN: 0430-0920
PMID: 2869971
Document Number: 551
The synthesis of the thiophenic analogue of metoprolol (VI) and of its related compound (VII) are described. Except for cardioselectivity at low doses, the thiophenic analogue of metoprolol behaves in a very similar way as this compound in all the aspects considered in a preliminary pharmacological study.

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Synthesis and beta-adrenoceptor blocking activity of thiophenic analogues of metoprolol