Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity
Chen, X.-f.; Wu, Y.-b.; Jin, J.; Wang, R.-z.; Wang, C.; Liu, J.
Yao Xue Xue Bao 45(2): 263-267
2010
ISSN/ISBN: 0513-4870 PMID: 21351438 Document Number: 639342
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
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