Top Abstract Purchase Related
Home
>
Node
>
Subnode

Anxiosedative properties of heteryl (aryl) -containing hexahydrobenzofuranon derivatives

Tiurenkov, I.N.; Bagmetova, V.V.; Ivanova, O.V.; Berestovitskaia, V.M.; Vasil'eva, O.S.; Ostrogliadov, E.S.

Eksperimental'naia i Klinicheskaia Farmakologiia 74(1): 15-18

2011

ISSN/ISBN: 0869-2092
PMID: 21476269
Document Number: 652625
The anxiosedative properties of 2-hydroxyimino-3-indolylyl(aryl)-4-oxo-2,3,4,5,6,7-hexahydrobenzofuranon derivatives have been studied using the open-field test, elevated plus-maze test, and conflict drinking procedure as developed by Vogel. It is established that all derivatives with both indole and aryl substituents produce a sedative effect. However, an anxiolytic effect is determined by the presence of indole substituent in the third position of the hexahydrobenzofuran molecule.

Document emailed within 1 workday
Secure & encrypted payments

Kabachnyĭ, V.I.; Chernykh, V.P.; Drogovoz, S.M.; Golubenko, I.A.; Bogutskaia, E.E. 1987: Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides Farmakologiia i Toksikologiia 50(1): 94-97
Tarzia, G.; Occelli, E.; Corsico, N.; Luzzani, F.; Barone, D. 1988: Benzodiazepine receptor ligands. Synthesis and preliminary pharmacological evaluation of some 3-aryl-6-thioalkyl-, 3-aryl-6-alkylsulphinyl-, 3-aryl-6-alkylsulphonyl-, and 3-aryl-6-alkoxy-1,2,4-triazolo[3,4-a]phthalazines Il Farmaco; Edizione Scientifica 43(2): 189-201
Zubchenko, V.G.; Kulik, M.I. 1973: Synthesis of azolidine derivatives with possible hypoglycemic action. IX. 2'-Arylsulfonyl-3-aryl-(alkyl-) derivatives of 2-iminothiazolidone-4 Farmatsevtychnyi Zhurnal 28(5): 28-33
Rudnicka, W.; Foks, H.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XXI. Synthesis and tuberculostatic activity of 4-aryl-1-pyrazinoylthiosemicarbazides and the products of their cyclization to 1,2,4-triazole-3-thione derivatives Acta Poloniae Pharmaceutica 43(6): 523-528
Zawadowski, T.; Skowron, A.A.; Suski, S.; Rump, S.; Jakowicz, I. 1995: Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinyl-butyl) derivatives of 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxyimide Acta Poloniae Pharmaceutica 52(2): 129-132
Osselaere, J.P. 1974: New 4 substituted derivatives of aryl-2 pyrido(2,3-d) pyrimidines Journal de Pharmacie de Belgique 29(2): 145-151
Calis, U.; Dalkara, S.; Ertan, M. 1992: Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives Arzneimittel-Forschung 42(5): 592-594
Sztanke, K.; Tkaczyński, T. 1997: Synthesis of new derivatives of 3-[4'-(2'-aminothiazolyl)]-8-aryl-7, 8-dihydro-6H-imidazo[2,1-c] [1,2,4]triazin-4-one Acta Poloniae Pharmaceutica 54(3): 223-224
Kozminykh, V.O.; Igidov, N.M.; Kozminykh, E.N.; Semenova, Z.N.; Andreichikov YuS 1992: Synthesis and antimicrobial activity of new 5-aryl-2-hydroxy-3(2H)-pyrrolinone derivatives Die Pharmazie 47(4): 261-263
Zankowska-Jasińska, W.; Borowiec, H.; Golus, J.; Kolasa, A.; Zaleska, B.; Krzywosiński, L.; Bogdal, M.; Przemyk, B. 1990: Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives Polish Journal of Pharmacology and Pharmacy 42(1): 49-58
Turło, J.; Zawadowski, T.; Rump, S.; Jakowicz, I.; Gidyńska, T.; Gałecka, E. 1994: Synthesis and pharmacological screening of some N,N'-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethylbicyclo-[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide Polish Journal of Pharmacology 46(5): 451-455
Pitrè, D.; Fumagalli, L.; Lorenzotti, E. 1972: Radiological contrast media. XXI. Iodine derivatives of aryl-(3-(N-alkylacylamino) phenoxy) acetic acids Il Farmaco; Edizione Scientifica 27(5): 408-418
Roma, G.; Di Braccio, M.; Grossi, G.; Marzano, C.; Simonato, M.; Bordin, F. 1998: Pyran derivatives. XX. 2-Aminochromone benzo-fused derivatives with antiproliferative properties Farmaco 53(7): 494-503
Safak, C.; Simsek, R.; Altas, Y.; Boydag, S.; Erol, K. 1997: 2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H indeno(1,2-b) pyridine derivatives studies and their calcium antagonistic activities Bollettino Chimico Farmaceutico 136(11): 665-669
Brzezińska, E.; Stańczak, A.; Ochocki, Z. 2003: Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties Acta Poloniae Pharmaceutica 60(1): 15-20
Kossakowski, J.; Zawadowski, T.; Kuśmierczyk, J. 1998: Synthesis of new N-[4-(4-aryl- and 4-heteroaryl-1-piperazinyl)butyl]derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with an expected anxiolytic activity Acta Poloniae Pharmaceutica 55(4): 315-318
Romeo, E.; Cavallaro, S.; Korneyev, A.; Kozikowski, A.P.; Ma, D.; Polo, A.; Costa, E.; Guidotti, A. 1993: Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex Journal of Pharmacology and Experimental Therapeutics 267(1): 462-471
Vittorio, F.; Santagati, N.A.; Lancetta, T.; Duro, F.; Arrigo Reina, R.; Cosentino, C. 1984: Alkyl and aryl derivatives of isoquinoline. II. Synthesis and pharmacologic activity of dialkylaminoalkyl esters of 1-chloro-3-carboxy-4-methylisoquinoline and the corresponding 4-phenyl derivative Il Farmaco; Edizione Scientifica 39(3): 217-228
Hilgeroth, A.; Langner, A. 2000: Plasma protein binding properties of dimeric 4-aryl-1,4-dihydropyridines as novel non peptidic HIV-1 protease inhibitors Die Pharmazie 55(7): 542-543
Silvestri, R.; Pagnozzi, E.; Troccoli, F.; Stefancich, G.; Massa, S.; Apuzzo, G.; Perazzi, M.E.; Artico, M.; Simonetti, G. 1995: Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives Farmaco 50(4): 227-238