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Acylated derivatives of 1,5-benzodiazepines. Part Ii

Nawrocka, W.; Liszkiewicz, H.; Nawojski, A.; Wilimowski, M.; Kedzierska-Goździk, L.; Barczyńska, J.; Wojewódzki, W.; Duś, E.; Szelag, A.; Rutkowska, M.

Polish Journal of Pharmacology and Pharmacy 43(6): 495-503

1991

ISSN/ISBN: 0301-0244
PMID: 1821044
Document Number: 368529
Acylated derivatives of 4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one (1) and of 2-methyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepino-2-carboxylic acid ethyl ester (10) were synthesized and preliminarily tested on their central activity. Acylation was carried out with alpha, beta-unsaturated acid chlorides, dicarboxylic acid monoester monochlorides, and dicarboxylic acid dichlorides. Compounds 2, 3, 11 and 12 had analgesic, compounds 4, 11 and 12--anticonvulsant, and compounds 3 and 11--antiaggressive properties.

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