Complexometric determination of diphosphonic acid derivatives. Part Ii
Podolska, M.; Białecka, W.; Kwiatkowska-Puchniarz, B.
Acta Poloniae Pharmaceutica 57(3): 159-165
2000
ISSN/ISBN: 0001-6837 PMID: 11143702 Document Number: 521375
The purpose of the study is to develop complexometric method determination of diphosphonic acid derivatives in pharmaceutical preparations used in the treatment of osteoporosis, vis., disodium etidronate, disodium tiludronate, disodium pamidronate and sodium alendronate. The visual end-point titration method involving either as complexing reagent Th(DCTA) or Th(EDTA) in the presence of xylenol orange or methyl thymol blue, uses the ability of these compounds to form complexes.