Intracellular mechanism of the action of imipramine and diazepam
Zakusov, V.V.; Profir'eva, R.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 80(10): 67-69
1975
ISSN/ISBN: 0365-9615 PMID: 1227627 Document Number: 87597
The content of noradrenaline during the action of antidepressant imipramine and a tranquilizer diazepam was determined in rats by differential centrifugation of the hypothalamus tissues. Imipramine was found to decrease the noradrenaline content in synaptosomes, whereas diazepam failed to evoke any similar effects. Thus, in the action mechanism of the first substance the adrenergic compound was of definite importance, while in the mechanism of the second one it took no part.