Intracellular mechanism for the action of inhibin on the secretion of the follicular-stimulating hormone and luteinizing hormone induced by LH-RH in vitro
Lecomte-Yerna, M.J.; Hazee-Hagelstein, M.T.; Charlet-Renard, C.; Franchimont, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 175(3): 385-388
1981
ISSN/ISBN: 0037-9026 PMID: 6168343 Document Number: 179359
The FSH secretion-inhibiting action of inhibin in vitro under basal conditions and also in the presence of LH-RH is suppressed by the addition of MIX, a phosphodiesterase inhibitor. In the presence of LH-RH, inhibin reduces significantly the intracellular level of cAMP in isolated pituitary cells. In contrast, the simultaneous addition of MIX and inhibin raises the cAMP level, and this stimulation is comparable to the increase observed when MIX is added alone. These observations suggest that one mode of action of inhibin could be mediated by a reduction in cAMP within the pituitary gonadotropic cell.