Top Abstract Purchase Related
Home
>
Node
>
Subnode

The distribution of imipramine and desipramine in rat brain regions after single and chronic administration of imipramine

Szymura-Oleksiak, J.; Panas, M.; Chruściel, W.

Polish Journal of Pharmacology and Pharmacy 36(1): 21-26

1984

ISSN/ISBN: 0301-0244
PMID: 6462958
Document Number: 230610
The regional distribution of imipramine (IMI) and desipramine (DMI) in rat brain after single and chronic oral administration of IMI was studied. The distribution of IMI and DMI in all examined brain regions was similar, except for hippocampus + septum. After chronic administration of IMI the disappearance of the parent drug and its metabolite was slowing down in all investigated brain regions as well as in the plasma. The accumulation of IMI and DMI after chronic treatment of IMI was significantly higher in plasma than in all examined brain regions.

Document emailed within 1 workday
Secure & encrypted payments

Duncan, G.E.; Paul, I.A.; Powell, K.R.; Fassberg, J.B.; Stumpf, W.E.; Breese, G.R. 1989: Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites Journal of Pharmacology and Experimental Therapeutics 248(1): 470-477
Sovner, R.; Orsulak, P.J. 1979: Excretion of imipramine and desipramine in human breast milk American Journal of Psychiatry 136(4a): 451-452
Morrow, P.L.; Hardin, N.J.; Bonadies, J. 1989: Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine Journal of Forensic Sciences 34(4): 1016-1020
Fischer, E.; Heller, B.; Spatz, H.; Reggiani, H. 1972: Thin-layer chromatographic assay of phenethylamine content of the rat brain and its changes after reserpine and imipramine administration Arzneimittel-Forschung 22(9): 1560
Kühne, G.E.; Knorr, W.; Perina, L.; Richter, H.; Rommel, B.; Sorger, R.; Waldow, N.; Fabiano, B.; Blosfeld, G.; Stöck, H. 1976: Experiences with Petylyl (desipramine) in antidepressive therapy. Double blind test with Pryleugan (imipramine) Zeitschrift für Arztliche Fortbildung 70(15): 835-839
Koszewska, I.; Beresewicz, M.; Puzyński, S.; Kalinowski, A. 1994: Psychotropic profile of essential antidepressants (amitriptyline, imipramine, desipramine, chlorimipramine): comparative study Psychiatria Polska 28(1): 27-38
Brański, P.; Pałucha, A.; Wierońska, J.; Kroczka, B.; Kownacka, B.; Pilc, A. 2000: Influence of chronic imipramine administration on the CaM-KIi activity in postsynaptic densities and synaptosomal plasma membrane fraction isolated from the rat frontal cortex and hippocampus Polish Journal of Pharmacology 52(6): 473-475
Daniel, W.; Syrek, M.; Janczar, L.; Boksa, J. 1995: The pharmacokinetics of promazine and its metabolites after acute and chronic administration to rats--a comparison with the pharmacokinetics of imipramine Polish Journal of Pharmacology 47(2): 127-136
Irwin, S.; Konohi, R.G. 1971: Single and repeat dose effects of imipramine and chlorpromazine in man Psychopharmacology Bulletin 7(4): 23-24
DeVane, C.L.; Simpkins, J.W. 1985: Pharmacokinetics of imipramine and its major metabolites in pregnant rats and their fetuses following a single dose Drug Metabolism and Disposition: the Biological Fate of Chemicals 13(4): 438-442
Wells, B.G.; Evans, R.L.; Ereshefsky, L.; Antal, E.J.; Lobeck, F.; Rawls, W.N.; Hamann, G.; Grimmig, J.; Smith, R.B. 1988: Clinical outcome and adverse effect profile associated with concurrent administration of alprazolam and imipramine Journal of Clinical Psychiatry 49(10): 394-399
Masubuchi, Y.; Takahashii, C.; Fujio, N.; Horie, T.; Suzuki, T.; Imaoka, S.; Funae, Y.; Narimatsu, S. 1995: Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats Drug Metabolism and Disposition: the Biological Fate of Chemicals 23(9): 999-1003
Hrdina, P.D. 1989: Imipramine binding sites in brain and platelets: role in affective disorders International Journal of Clinical Pharmacology Research 9(2): 119-122
Ruscák, M.; Orlický, J.; Pogády, J. 1972: The effect of centrophenoxine, lithium and imipramine on the metabolism of rat brain cortex slices in vitro Activitas Nervosa Superior 14(2): 137
Rozhanets, V.V.; Rusakov, D.I.; Val'dman, A.V. 1982: Affinity of various antidepressive agents to imipramine receptors of synaptic membranes in mouse brain Biulleten' Eksperimental'noi Biologii i Meditsiny 94(10): 42-43
Chrzanowski, J. 1977: Imipramine in the treatment of chronic sciatic pains Wiadomosci Lekarskie 30(18): 1439-1440
Bijak, M.; Tokarski, K. 1994: Prolonged administration of imipramine and (+)-oxaprotiline, but not citalopram, results in sensitization of the rat hippocampal CA1 neurons to serotonin ex vivo Polish Journal of Pharmacology 46(3): 163-167
Gandolfi, O.; Barbaccia, M.L.; Costa, E. 1984: Comparison of iprindole, imipramine and mianserin action on brain serotonergic and beta adrenergic receptors Journal of Pharmacology and Experimental Therapeutics 229(3): 782-786
Maj, J.; Rogóz, Z.; Skuza, G.; Sowińska, H. 1989: The effect of repeated administration of imipramine, citalopram and mianserin on responsiveness of central serotonergic, alpha 2-adrenergic and cholinergic system in mice Polish Journal of Pharmacology and Pharmacy 41(4): 313-319
Ehlert, F.J.; Delen, F.M.; Yun, S.H.; Liem, H.A. 1990: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart Journal of Pharmacology and Experimental Therapeutics 253(1): 13-19