Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats
Serdiuk, S.E.; Gmiro, V.E.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 98(2): 236-241
2012
ISSN/ISBN: 0869-8139 PMID: 22650067 Document Number: 662552
Intramuscular (i.m.) administration ofdiazepam in a dose of 10 mg/kg and adrenaline in a dose of 0.2 mg/kg prevents generalized clonic-tonic pentylenetetrazol (PTZ) seizures in 75-80 % of rats, but only in 35-40 % of rats it prevents local clonic PTZ seizures. In the above mentioned dose, diazepam causes a strong sedation, but adrenaline does not cause a sedative effects. The combined administration of diazepam and adrenaline in threshold independently ineffective doses prevents both clonic-tonic and clonic PTZ seizures in 80 % of rats without a sedation development. The basis for mechanism of potentiation of anticonvulsant action of diazepam is the stimulation of gastric mucosa afferents by adrenaline.