Mechanism of action of clotrimazole. I. Study of the principal action on Candida albicans
Iwata, K.; Yamaguchi, H.
Nihon Saikingaku Zasshi. Japanese Journal of Bacteriology 28(6): 513-521
1973
ISSN/ISBN: 0021-4930 PMID: 4597146 Document Number: 66754
The min. inhibitory conc. of clotrimazole ranged from 0.5 to 4 mu g/ml against clinical isolates of C. albicans. Clotrimazole was fungistatic at 2 mu g/ml and fungicidal above 20 mu g/ml. Results presented suggest that clotrimazole may act primarily by damaging the permeability barrier of sensitive organisms.
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