Synergistic action of clotrimazole and certain anionic surfactants may be due to ion pair formation
Pedersen, M.
Acta Pharmaceutica Nordica 2(6): 367-370
1990
ISSN/ISBN: 1100-1801 PMID: 2095795 Document Number: 354827
A synergistic effect of clotrimazole and certain anionic surfactants against a strain of Candida albicans was confirmed. Measurement of apparent partition coefficients indicated that lipophilic ion pairs between clotrimazole and anionic surfactants were formed. It is suggested that the synergistic effect of the drugs may be due to ion pair formation.
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