The synergistic action of pyrazolopyrimidines and pentavalent antimony against Leishmania donovani and L. braziliensis
Martinez, S.; Looker, D.L.; Berens, R.L.; Marr, J.J.
American Journal of Tropical Medicine and Hygiene 39(3): 250-255
1988
ISSN/ISBN: 0002-9637 PMID: 2845824 Document Number: 315965
Amastigotes of L. donovani of an allopurinol (A)-sensitive Sudan I strain and an A-resistant Khartoum strain in continuous human macrophage cell cultures were treated with a combination of allopurinol riboside (AR) and pentostam report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.AS.