Effect of new diamidines against Leishmania donovani infection
Chauhan, P.M.; Iyer, R.N.; Shankhdhar, V.; Guru, P.Y.; Sen, A.B.
Indian Journal of Experimental Biology 31(2): 196-198
1993
ISSN/ISBN: 0019-5189 PMID: 8500833 Document Number: 419207
The impact of interamidine distance on antileishmanial activity of new aryldiamidines have been evaluated against amastigotes of Leishmania donovani in hamster. Of the 20 compounds tested, only four (2,8-diamidino-9,10-dihydrodibenzoxepin; 2,7-diamidinoxanthone; 2,7-diamidinothioxanthone and 2,7-diamidinoxanthene) showed significant inhibition (more than 80%) of multiplication of amastigotes in spleen. The interamidine distance in the structure appears to have bearing on antileishmanial activity. The observations made are likely to evoke new understanding on the structure activity relationship of diarylamidines.