Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action
D'Souza, R.S.; Bhandare, P.N.; Dhume, V.G.
Indian Journal of Physiology and Pharmacology 34(4): 252-254
1990
ISSN/ISBN: 0019-5499 PMID: 1966047 Document Number: 359989
Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like clonidine, high doses of phentolamine and cimetidine aggravate gastric lesions per se, suggesting that all three may be acting at a common 'receptor' site, possibly the imidazoline-preferring receptor (IPR).