Growth phase in relation to the lethal action of tamoxifen on Candida albicans
Beggs, W.H.
Research Communications in Molecular Pathology and Pharmacology 88(1): 115-118
1995
ISSN/ISBN: 1078-0297 PMID: 7620832 Document Number: 440213
Tamoxifen, a drug used to treat breast cancer, might have antifungal potential. The fungicidal activity of tamoxifen against Candida albicans surpassed that of the most active of the imidazole-type drugs. At 15-20 microM, tamoxifen rapidly killed yeast cells in stationary phase as well as in logarithmic phase, whereas imidazoles at this level generally do not exert significant lethal activity against stationary phase organisms.