Synthesis and biological evaluation of some new substituted naphthoquinones
Habib, N.S.; Bekhit, A.A.; Park, J.Y.
Bollettino Chimico Farmaceutico 142(5): 232-238
2003
ISSN/ISBN: 0006-6648 PMID: 14526658 Document Number: 554384
Two novel series of 1,4-naphthoquinone derivatives have been synthesized namely; N-ethoxycarbonyl-2-ethoxycarbonyloxy-3- alkyl-1,4-naphthoquinon-1-substituted phenylhydrazones 3a-f and 2-chlorocetyloxy-3-alkyl-1,4-naphthoquinone-1-substituted phenylhydrazones 4a-d. The antimicrobial activity as well as anticancer activity of these compounds have been evaluated. The acute toxicity of the active compounds was determined.
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