Diversity in lipid a binding ligands: comparison of lipid a monoclonal antibodies with rBPI23
Appelmelk, B.J.; Qing, A.Y.; Helmerhorst, E.J.; Maaskant, J.J.; Abraham, P.R.; Thijs, L.G.; MacLaren, D.M.
Progress in Clinical and Biological Research 392: 453-463
1995
ISSN/ISBN: 0361-7742 PMID: 8524952 Document Number: 443254
1. Mabs with a high affinity for free lipid A do not bind when it is covalently linked, i.e. in the form of LPS. 2. Lipid A-binding Mabs may be divided into three categories: I. Monoreactive Mabs that bind to the hydrophillic backbone of lipid A II. Polyreactive Kdo Mabs III. Polyreactive Mabs that bind by hydrophobic interactions 3. rBPI23 binds either free or covalently linked lipid A.