The use of monoclonal antibodies to lipid A for the correction of the hemodynamic disorders in endotoxemia
Rumiantsev, A.G.; Kasatkin, V.N.; Blokhin, B.M.; Golubykh, V.L.; Borovikov, D.V.; Vlasik, T.N.; Kanaeva, E.S.; Kalantarov, G.F.
Gematologiia i Transfuziologiia 38(1): 31-33
1993
ISSN/ISBN: 0234-5730 PMID: 8020702 Document Number: 407533
Endotoxemia induced by gram-negative bacteria leads to endotoxic shock pathogenetically stemming from the integral component of the bacterial wall--lipid A. The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration. ReLPS isolated from Salmonella Minnesota was used as an antigen. Administration of the complex monoclonal antibodies-endotoxin caused no hemodynamic impairment.