Age-related changes in adenylate cyclase activity, lipid composition and lipid peroxidation in rat intestinal mucosa: comparison with the frequency of spontaneous tumors
Bershteĭn, L.M.; Kovaleva, I.G.
Voprosy Onkologii 31(8): 85-89
1985
ISSN/ISBN: 0507-3758 PMID: 4036069 Document Number: 262497
The study used 3, 7, 16 and 22 month-old male rats bred at the animal farm of the Institute. Identical age-related changes were established in the level of free cholesterol, its esters, free cholesterol/phospholipids and sphingomyelin/lecithin ratios in ascending and descending colon mucosa. Unlike descending colon mucosa, the basal and hormone-stimulating activity of adenylate cyclase and rate of lipid peroxidation in the mucosa of the ascending colon of 22 month-old animals were lower than in 16 month-old rats. The results are compared with the available data on the predominant localization of spontaneous tumors in the proximal (ascending) part of rat's intestine.