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The interrelationship of the processes of lipid peroxidation and lipid phospholipase hydrolysis in the synaptosomes

Nikushkin, E.V.; Kryzhanovskiĭ, G.N.; Mikhaleva, L.I.; Bordiukov, M.M.; Kaplun, A.L.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(2): 174-177

1989

ISSN/ISBN: 0365-9615
PMID: 2923973
Document Number: 336008
The influence of Fe2+, alpha-tocopherol, phospholipase A2 and mepacrine on the activity of lipid peroxidation (LPO) and phospholipid hydrolysis (PLH) was studied in synaptosomes. It was established that there is the tight direct interconnection between LPO and PLH in synaptosomes. It is assumed that activation of endogenous phospholipases in neurons is one of the causes of uncompensated LPO-activation during epileptogenesis.

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