Synthesis and pharmacological study of alpha-phenyl-1-adamantanemethanamine
Marakos, P.; Foscolos, G.B.; Fytas, G.; Kolocouris, N.; Vamvakidès, A.
Annales Pharmaceutiques Francaises 49(4): 214-221
1991
ISSN/ISBN: 0003-4509 PMID: 1781604 Document Number: 376040
The alpha-phenyl-1-adamantanemethanamine 2 was synthesized and its pharmacological action was studied on mice. The behavior effects obtained with this compound (at low dose) as well as the antagonism of the convulsions and the lethality (induced by the amine 2 at high dose) by desimipramine, N-linoleylGABA or N-linoleylglycine, could suggest the existence of glutamatergic (NMDA), anti-GABAergic and antiglycinergic components in the action mechanism of this adamantanamine.
Document emailed within 1 workday
Related Documents
Duro, F.; Condorelli, P.; Arrigo Reina, R. 1972: Synthesis and pharmacological activity of alkylamido-derivatives of 4-phenyl-3-isocoumarin acid Bollettino Chimico Farmaceutico 111(12): 740-748Banci, F.; Bulgini, M.J.; Tubaro, E. 1971: Synthesis and some pharmacological activities of 4-alkylamino-2,3-dimethyl-l-phenyl-3-pyrazolin-5-one derivatives Arzneimittel-Forschung 21(11): 1665-1667
Diurno, M.V.; Cristinziano, A.; Mazzoni, O.; Piscopo, E.; Bolognese, A. 1995: Synthesis and antimicrobial activity of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones Farmaco 50(2): 143-148
Zawadzka, J.; Bogdal, M. 1984: Thiazole derivatives. V. Synthesis and pharmacological screening of amides of 4-phenyl-5-thiazolecarboxylic acids Acta Poloniae Pharmaceutica 41(6): 633-640
Mirek, J.; Chojnacka-Wójcik, E.; Tatarzyńska, E.; Wiczyńska, B. 1985: Synthesis of 3-phenyl-3-phenylthiopropionic acids, amides, amines and studies on their pharmacological properties Il Farmaco; Edizione Scientifica 40(9): 701-708
Bakinovskiĭ, L.V.; Gomtsian, A.R.; Baĭramova, N.E.; Kochetkov, N.K. 1985: Synthesis of oligosaccharide fragments of O-specific polysaccharides of Shigella flexneri. III. Synthesis of the tetrasaccharide Glc alpha 1-3Rha alpha 1-2(Glc alpha 1-3)Rha alpha 1-OMe and the pentasaccharide GlcNAc beta 1-2(Glc alpha 1-3)Rha alpha 1-2(Glc alpha 1-3)Rha alpha 1-OMe Bioorganicheskaia Khimiia 11(5): 655-661
Costakis, E.; Tsatsas, G. 1978: Synthesis and pharmacological properties of some alpha-phenylalkylamides and alpha-phenylalkylamines Annales Pharmaceutiques Francaises 36(7-8): 349-360
Bonacchi, G.; Agostini, O.; Fedi, M.; Bacciarelli, C.; Boni, P.; Castellucci, A.; Perretti, F.; Manzini, S. 1988: Resolution and pharmacological properties of the enantiomers of the potent alpha-adrenoceptor antagonist 1-[2-ethoxy-2-(3'-pyridyl)ethyl]-4-(2'-methoxy-phenyl)piperazine Arzneimittel-Forschung 38(5): 650-654
Hullot, P.; Poudrel, J.M.; Muller, A.; Escale, R.; Rossi, J.C.; Girard, J.P.; Bonne, C. 1997: Synthesis and biochemical/pharmacological profile of the novel leukotriene B4 receptor antagonist sodium (1S*, 3S*)-1-hydroxy-3-[(3 R*S*,E)-3-hydroxy-7-phenyl-1-hepten-1-yl]-1-cyclohexane acetate Arzneimittel-Forschung 47(1): 51-58
Ziegelhoeffer A.; De Jong J.W.; Ferrari R.; Turi Nagy L. 1989: Anti-fertility agents 45. Synthesis and activity of 1,2-cis-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-phenyl-5-methoxyindane European Journal of Medicinal Chemistry 24(2): 193-197
Coudert, P.; Rubat, C.; Couquelet, J.; Tronche, P. 1990: Synthesis of 6-[(4-imidazol-1-yl)-phenyl]-4-phenyl 4,5-dihydro-2H-pyridazin-3-one: a potential blood platelet aggregation inhibitor Journal de Pharmacie de Belgique 45(3): 191-195
Zabska, R.; Jakóbiec, T.; Dobek, R.; Wilimowski, M.; Barczyńska, J.; Kedzierska-Goździk, L.; Wojewódzki, W.; Rutkowska, M.; Duś, E.; Szelag, A. 1991: Synthesis and pharmacological properties of derivatives of alpha-amino-beta-(p-chlorobenzoyl)-propionic acid and alpha-amino-gamma-(p-chlorophenyl)-tetrahydrofuran-2-one Polish Journal of Pharmacology and Pharmacy 43(4): 271-280
Pahwa, G.S.; Anand, K.K.; Johri, S.; Gupta, S.; Atal, C.K. 1987: Pharmacological and toxicological investigations of 7-hydroxy-4-phenyl-3(4-hydroxy-phenyl)-coumarin (OV1) Indian Journal of Experimental Biology 25(7): 450-453
Fanelli, O. 1973: Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg Arzneimittel-Forschung 23(6): 810-816
Islam, M.; Siddiqui, A.A. 2010: Synthesis, antituberculostatic, antifungal and antibacterial activities of 3-substituted phenyl-6-substituted phenyl-1,2,4-triazolo[4,3-b]pyridazines Acta Poloniae Pharmaceutica 67(5): 555-562
Morgenstern, O.; Besch, A.; Richter, P. 1988: Synthesis and biological activity of 5-phenyl-1,3,4-benzotriazepines. 14. the reactions of 2-thioxo-5-phenyl-1,3,4-benzotriazepines Die Pharmazie 43(11): 760-761
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Lebedeva, M.N.; Kovalenko, F.P.; Dzhabarova, V.I.; Lychko, N.D.; Baiandina, D.G.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 55-57
Biniecki, S.; Horoszkiewicz, Z. 1974: Synthesis of indolyl-3-acetic acid (1-phenyl-2-3-dimethyl-5-oxo-4-pyrazolyl) amide of 3-indolylacetic acid and N-methyl-(1-phenyl-2,3-3-indolylacetic acid Acta Poloniae Pharmaceutica 31(2): 151-155
Shostakovskii, M.F.; Prilezhaeva, E.N.; Shapiro, E.S. 1951: Synthesis of sulfuric substances based on acetylene and vinyl ethers; synthesis of alpha-alkoxyethylmercaptans and alpha, alpha'-dialkoxydiethylsulfides by the effect of hydrogen sulfide on vinyl ethers Izvestiia Akademii Nauk Sssr Otdelenie Khimicheskikh Nauk 3: 284-294
Saturnino, C.; Capasso, A.; Saturnino, P.; De Martino, G.; Sorrentino, L.; Lancelot, J.C.; Robba, M. 1997: A new class of pyrrolidin-2-ones: synthesis and pharmacological study Journal de Pharmacie de Belgique 52(2): 57-60