Substituted phenylthiophenylamines with antiinflammatory activity
Bethegnies, G.; Marcincal-Lefebvre, A.; Brunet, C.; Cazin, M.; Damas, J.
Farmaco 44(7-8): 683-694
1989
ISSN/ISBN: 0014-827X PMID: 2590366 Document Number: 335265
Several acid and closely related non acid derivatives of 2-phenylthio- and 4-phenylthio-N-acyl phenylamines have been synthesized and tested in vivo, on the carrageenan RFE assay, and in vitro, on prostaglandin synthesis inhibition assay. Compound (XV c), bearing a propanoic acid substituent together with a p-chlorobenzoyl group situated on nitrogen atom in the 2-position, showed a 79% edema reduction (300 mg/kg p.o.) 6 hours after carrageenan injection, but no activity in vitro. The benzyl alcohols (XIV m) and (XIV n), on the contrary, inhibited PG synthesis; their lack of activity in vivo could be interpreted as the result of their oxidiation in the inactive benzoic acids (XIV g) and (XIV h).