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FCE 20700, a cytoprotective PGE2 derivative, does not interfere with the antiinflammatory activity of indomethacin

Ceserani, R.; Arrigoni, C.; Mizzotti, B.; Tremolada, L.; Ferrari, M.; Buttinoni, A.

International Journal of Tissue Reactions 5(4): 349-351

1983

ISSN/ISBN: 0250-0868
PMID: 6689489
Document Number: 206685
A study was made of the interaction between FCE 20700 (11-deoxy-13,14-didehydro-16(S)-methyl-PGE2 methylester) at a fixed dose of 250 mcg/kg and the ulcerogenic and antiinflammatory effect of indomethacin (I) on rat carrageenin paw edema. The combination tested showed the same antiinflammatory effect as I alone: potency ratio FCE 20700 + I/I was 1.03, demonstrating the lack of interaction between the two compounds. Moreover the gastric lesions in FCE 20700 + I treated rats were markedly reduced, allowing the dosage of I to be increased by about three times without increasing its ulcerogenic effect.

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