Synthesis of lipid a analogs: achievements and perspective
Gorbach, V.I.; Solov'eva, T.F.; Ovodov, I.S.
Bioorganicheskaia Khimiia 14(4): 437-452
1988
ISSN/ISBN: 0132-3423 PMID: 3048269 Document Number: 312840
Data on the synthesis of analogues of lipid A, a biologically active fragment of gram-negative bacteria's lipopolysaccharides, are summarized. Main types of the compounds obtained are systematized, and problems of the synthesis of various parts of the molecule considered. The results of studying biological activity of lipid A analogues are discussed, which led to some conclusions on the structure-function relation. Perspectives of further studies are briefly outlived.