Synthesis of various acyclic analogs of pyrimidine nucleosides
Roveri, P.; Cavrini, V.; Gatti, R.
Il Farmaco; Edizione Scientifica 39(4): 346-352
1984
ISSN/ISBN: 0430-0920 PMID: 6327364 Document Number: 241169
As acyclic analogues of pyrimidine nucleosides, 1-[2-(2,3- dihydroxypropyloxy )ethyl]pyrimidines (III a-c) and 1-[[3-(2,3- dihydroxypropyloxy )-2-hydroxy]propyl]pyrimidines (III d-f) were synthesized and tested for in vitro activity against herpes simplex virus type 1. The compounds exhibited no significant antiherpetic activity.
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