Effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus
Roubal, J.; Závada, V.; Vejsada, J.; Boldogh, I.; Vonka, V.
Acta Virologica 23(4): 314-318
1979
ISSN/ISBN: 0001-723X PMID: 40418 Document Number: 152165
The incorporation of 3H-thymidine and 3H-deoxycytidine into acidoprecipitable fraction of hamster cells transformed by herpes simplex viruses type 1 and type 2 and of 3H-thymidine into hamster cells transformed by human cytomegalovirus was found to be resistant to the action of cytosine arabinoside. More 3H-thymidine was incorporated into these cells in the presence than in the absence of the drug. Similar stimulaton of 3H-thymidine uptake could be achieved by using unlabelled deoxycytidine instead of cytosine arabinoside. Incorporation of both nucleosides into spontaneously and SV40 transformed cells was efficiently inhibited by the drug.