Study of reverse transcriptase selectivity. Substrate properties of new 2',3'-unsaturated acyclic nucleotide analogs
Shirokova, E.A.; Shipitsyn, A.V.; Semizarov, D.G.
Molekuliarnaia Biologiia 29(2): 461-471
1995
ISSN/ISBN: 0026-8984 PMID: 7540255 Document Number: 446198
A new series of nucleotide analogs, (Z)-pyrophosphoryl (phosphonyloxymethyl) but-2-enyl derivatives of pyrimidines and purines, was synthesized. Their substrate and inhibitory properties toward some DNA polymerases and reverse transcriptases were evaluated. They were shown to be selective inhibitors of HIV reverse transcriptase. The structure-substrate properties relationships for nucleotide analogs were discussed.
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