Search for new non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-1 RT)
Brzezińska, E.; Glinka, R.
Acta Poloniae Pharmaceutica 59(5): 379-386
2002
ISSN/ISBN: 0001-6837 PMID: 12602800 Document Number: 542592
The derivatives of dibenzoxazocinone, dibenzoxadiazocine, dibenzoxadiazonine, and benzodiazepine systems were synthesized as potential lead compounds for inhibitors of HIV-1 reverse transcriptase. The suggested structures were derived from analysis of the described spatial and physicochemical requirements for HIV-1 RT inhibitors. All of the evaluated compounds (apart from the oxadiazocine derivatives) showed a week inhibitory activity on recombinant HIV-1 RT from Escherichia coli.
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