Multi-drug resistant HIV-1 reverse transcriptase genotype in children treated with dual nucleoside reverse transcriptase inhibitors (NRTIs)
Engchanil, C.; Kosalaraksa, P.; Lulitanond, V.; Lumbiganon, P.; Chantratita, W.
Journal of the Medical Association of Thailand 89(10): 1713-1720
2006
ISSN/ISBN: 0125-2208 PMID: 17128848 Document Number: 2649
Background. Multi-drug resistant HIV mutants have been reported after prolonged dual antiretroviral therapy.Objective: To evaluate the prevalence and resistance pattern in HIV-infected children treated with dual NRTIs.Material and Method. Records of HIV-infected children treated with dual NRTIs at Srinagarind Hospital, Khon Kaen University, Thailand, were reviewed for baseline data and their consensually-stored plasma were checked for the occurrence of HIV mutants by genotyping.Results: Fifty-seven HIV-infected children were treated with dual NRTI regimens (2 7 males; 30 females). The median age and median CD4+ T-lymphocyte at genotypic testing were 83.5 months and 10.9%, respectively. The median duration of ARV therapy was 22 months. More than half the children (42) were on zidovudine and didanosine. A set of three or more nucleoside analog mutations (NAMs), conferring multi-dideoxynucleoside resistance, was found in 60% of the cases.Conclusion: High percentages of NAMs were found in HIV-infected children previously on dual ARV therapy for long periods. Genotypic testing was helpful in designing the second antiretroviral regimen.
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