Ester derivatives of nucleoside inhibitors of reverse transcriptase: I. Molecular transport systems for 3'-azido-3'-deoxythymidine and 2',3'-didehydro-3'-deoxythymidine
Berezovskaia, I.V.; Chudinov, M.V.
Bioorganicheskaia Khimiia 31(4): 339-356
2005
ISSN/ISBN: 0132-3423 PMID: 16119453 Document Number: 584786
The methods of synthesis of the derivatives of nucleoside analogues esterified with various aliphatic, aromatic, and heteroaromatic acids and the construction from them of molecular transport systems that involve lipids, carbohydrates, peptides, and amino acids are discussed. The characteristics of the biological activity of a number of such systems are described.
Document emailed within 1 workday
Related Documents
Berezovskaia, I.V.; Chudinov, M.V. 2005: Ester derivatives of nucleoside inhibitors of reverse transcriptase: II. Molecular systems for combined therapy with 3'-azido-3'-deoxythymidine and 2',3'-didehydro-3'-deoxythymidine Bioorganicheskaia Khimiia 31(5): 451-465Engchanil, C.; Kosalaraksa, P.; Lulitanond, V.; Lumbiganon, P.; Chantratita, W. 2006: Multi-drug resistant HIV-1 reverse transcriptase genotype in children treated with dual nucleoside reverse transcriptase inhibitors (NRTIs) Journal of the Medical Association of Thailand 89(10): 1713-1720
Ahluwalia, G.S.; Gao, W.Y.; Mitsuya, H.; Johns, D.G. 1996: 2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis Molecular Pharmacology 50(1): 160-165
Nicolas, F.; De Sousa, G.; Thomas, P.; Placidi, M.; Lorenzon, G.; Rahmani, R. 1995: Comparative metabolism of 3'-azido-3'-deoxythymidine in cultured hepatocytes from rats, dogs, monkeys, and humans Drug Metabolism and Disposition: the Biological Fate of Chemicals 23(3): 308-313
Chow, H.H.; Li, P.; Brookshier, G.; Tang, Y. 1997: In vivo tissue disposition of 3'-azido-3'-deoxythymidine and its anabolites in control and retrovirus-infected mice Drug Metabolism and Disposition: the Biological Fate of Chemicals 25(4): 412-422
Ruţă, S.M.; Cernescu, C. 1994: Syncytium forming capacity of HIV 1 strains in inhibited by pretreatment of CD4 expressing cells with 3'-azido-3'-deoxythymidine but not by alpha interferon Revue Roumaine de Virologie 45(3-4): 171-183
Brzezińska, E.; Glinka, R. 2002: Search for new non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-1 RT) Acta Poloniae Pharmaceutica 59(5): 379-386
2000: Non-nucleoside reverse transcriptase inhibitors. First line therapy MMW Fortschritte der Medizin 142(3 Suppl): 34-35
Tarby, C.M. 2004: Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors Current Topics in Medicinal Chemistry 4(10): 1045-1057
Wainberg, M.A.; Sawyer, J.P.C.; Montaner, J.S.G.; Murphy, R.L.; Kuritzkes, D.R.; Raffi, F. 2005: Challenges for the clinical development of new nucleoside reverse transcriptase inhibitors for HIV infection Antiviral Therapy 10(1): 13-28
Stankov, M.V.; Lücke, T.; Das, A.M.; Schmidt, R.E.; Behrens, G.M.N. 2007: Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors Antiviral Therapy 12(2): 205-216
Flandre, P.; Descamps, D.; Joly, V.; Meiffrédy, V.; Tamalet, C.; Izopet, J.; Aboulker, J-Pierre.; Brun-Vézinet, Fçoise. 2003: Predictive factors and selection of thymidine analogue mutations by nucleoside reverse transcriptase inhibitors according to initial regimen received Antiviral Therapy 8(1): 65-72
Vemula, S.; Kerr, S.; Pancharoen, C.; Siripong, A.; Kosalaraksa, P.; Engchanil, C.; Chuamchaitrakool, A.; Intasan, J.; Lumbiganond, P.; Phanuphak, P.; Ananworanich, J. 2007: Incidence and risk factors for non-nucleoside reverse transcriptase inhibitors (NNRTI)-related rash in Thai children with HIV infection Journal of the Medical Association of Thailand 90(11): 2437-2441
Mankhatitham, W.; Luaengniyomkul, A.; Manosuthi, W. 2012: Lipid profile changes in Thai HIV and tuberculosis co-infected patients receiving non-nucleoside reverse transcriptase inhibitors-based antiretroviral therapy Journal of the Medical Association of Thailand 95(2): 163-169
Sachdeva, R.K.; Wanchu, A.; Bagga, R.; Malla, N.; Sharma, M. 2010: Effect of non-nucleoside reverse transcriptase inhibitors on cytokine, chemokine, and immunoglobulin profiles in serum and genital secretions of HIV-infected women Journal of Interferon and Cytokine Research: the Official Journal of the International Society for Interferon and Cytokine Research 30(5): 299-310
Ramachandran, G.; Kumar, A.K.Hemanth.; Ponnuraja, C.; Ramesh, K.; Rajesh, L.; Chandrasekharan, C.; Swaminathan, S. 2013: Lack of association between plasma levels of non-nucleoside reverse transcriptase inhibitors & virological outcomes during rifampicin co-administration in HIV-infected TB patients Indian Journal of Medical Research 138(6): 955-961
Arenas-Pinto, A.; Bhaskaran, K.; Dunn, D.; Weller, I.V.D. 2008: The risk of developing peripheral neuropathy induced by nucleoside reverse transcriptase inhibitors decreases over time: evidence from the Delta trial Antiviral Therapy 13(2): 289-295
Balzarini, J.; De Clercq, E. 1987: Differential affinities of pyrimidine nucleoside analogues for deoxythymidine and deoxycytidine kinase determine their incorporation into murine leukemia L1210 cells Acta Biochimica Polonica 34(2): 63-77
Song, L.; Ding, S.; Ge, Z.; Zhu, X.; Qiu, C.; Wang, Y.; Lai, E.; Yang, W.; Sun, Y.; Chow, S.A.; Yu, L. 2018: Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells British Journal of Pharmacology 175(8): 1241-1259
Mesplet, N.; Morin, P.; François, C.; Agrofoglio, L.A. 2001: Simultaneous quantitation of nucleoside HIV-1 reverse transcriptase inhibitors by short-end injection capillary electrochromatography on a beta-cyclodextrin-bonded silica stationary phase Journal of Chromatography A 927(1-2): 161-168