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In vivo tissue disposition of 3'-azido-3'-deoxythymidine and its anabolites in control and retrovirus-infected mice

Chow, H.H.; Li, P.; Brookshier, G.; Tang, Y.

Drug Metabolism and Disposition the Biological Fate of Chemicals 25(4): 412-422

1997

ISSN/ISBN: 0090-9556
PMID: 9107539
Document Number: 470847
The in vivo disposition of AZT anabolites after a single dose administration of AZT is tissue-specific in mice and experimentally induced chronic retrovirus infection resulted in the most significant changes in the distribution of AZT into the lymph nodes and in the phosphorylation of AZT in this important target tissue. Further studies are needed to relate the tissue-specific disposition of AZT anabolites to the therapeutic problems encountered with AZT treatment.

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Berezovskaia, I.V.; Chudinov, M.V. 2005: Ester derivatives of nucleoside inhibitors of reverse transcriptase: I. Molecular transport systems for 3'-azido-3'-deoxythymidine and 2',3'-didehydro-3'-deoxythymidine Bioorganicheskaia Khimiia 31(4): 339-356
Berezovskaia, I.V.; Chudinov, M.V. 2005: Ester derivatives of nucleoside inhibitors of reverse transcriptase: II. Molecular systems for combined therapy with 3'-azido-3'-deoxythymidine and 2',3'-didehydro-3'-deoxythymidine Bioorganicheskaia Khimiia 31(5): 451-465
Nicolas, F.; De Sousa, G.; Thomas, P.; Placidi, M.; Lorenzon, G.; Rahmani, R. 1995: Comparative metabolism of 3'-azido-3'-deoxythymidine in cultured hepatocytes from rats, dogs, monkeys, and humans Drug Metabolism and Disposition: the Biological Fate of Chemicals 23(3): 308-313
Ruţă, S.M.; Cernescu, C. 1994: Syncytium forming capacity of HIV 1 strains in inhibited by pretreatment of CD4 expressing cells with 3'-azido-3'-deoxythymidine but not by alpha interferon Revue Roumaine de Virologie 45(3-4): 171-183
Soliman, G.A. 2000: Tissue distribution and disposition kinetics of enrofloxacin in healthy and E. coli infected broilers Deutsche Tierärztliche Wochenschrift 107(1): 23-27
Bachur, N.R.; Moore, A.L.; Bernstein, J.G.; Liu, A. 1970: Tissue distribution and disposition of daunomycin (NCS-82151) in mice: fluorometric and isotopic methods Cancer ChemoTherapy Reports 54(2): 89-94
Heusse, D.; Marlard, M.; Bredenbac, J.; Decouvelaere, B.; Leroy, J.P.; Bieder, A.; Jumeau, H. 1985: Disposition of 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes Arzneimittel-Forschung 35(9): 1431-1436
Moo, K.S.; Radhakrishnan, S.; Teoh, M.; Narayanan, P.; Bukhari, N.I.; Segarra, I. 2010: Disposition and tissue distribution of imatinib in a liposome formulation after intravenous bolus dose to mice Yao Xue Xue Bao 45(7): 901-908
Kallio, A.; Seppänen, P.; Alhonen-Hongisto, L.; Jänne, J. 1983: Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration Cancer Research 43(1): 324-327
Sergeev, A.A.; Shishkina, L.N.; Zhukov, V.A.; Sergeev, A.N.; Petrishchenko, V.A.; Fankin, I.V.; P'iankov, O.V.; Riabchikova, E.I.; Malkova, E.M.; Vorob'ev, A.A. 2004: Pulmonary cell susceptibility in mice and rats to influenza virus when infected in vivo and in vitro Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2004(8): 15-18
Spaccapelo, R.; Romani, L.; Tonnetti, L.; Cenci, E.; Mencacci, A.; Del Sero, G.; Tognellini, R.; Reed, S.G.; Puccetti, P.; Bistoni, F. 1995: TGF-beta is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans Journal of Immunology 155(3): 1349-1360
El-Hawey, A.M.; Lan, S.J.; Schreiber, E.C. 1976: Autoradiographic and tissue distribution studies on a nitrovinylfuran derivative (SQ 18506 14C) in S. mansoni infected mice Egyptian Journal of Bilharziasis 3(1): 73-78
Hassan, M.M.; Afify, H.; el-Dairouty, A.; Shalaby, M.; Assal, K.; Monib, M.El-Salahy.M.M.; el-Kadi, M.A. 2005: Detection of altered secondary lymphoid-tissue chemkine responsiveness in Balb/c mice infected with Schistosoma mansoni Journal of the Egyptian Society of Parasitology 35(3): 1009-1017
Xia, S.X.; Xu, H.Y.; Chen, N.Q.; Shen, B.F. 1982: The in vivo disposition of diethyllipoamide Zhongguo Yao Li Xue Bao 3(2): 136-139
Lammas, D.A.; Mitchell, L.A.; Wakelin, D. 1989: Genetic control of eosinophilia. Analysis of production and response to eosinophil-differentiating factor in strains of mice infected with Trichinella spiralis Clinical and Experimental Immunology 77(1): 137-143
Pedrazzini, T.; Hug, K.; Louis, J.A. 1987: Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guérin in mice. Assessment by elimination of T cell subsets in vivo Journal of Immunology 139(6): 2032-2037
Song, S.; Suzuki, H.; Terasaki, T.; Lemaire, M.; Sugiyama, Y. 1998: Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo Journal of Pharmacology and Experimental Therapeutics 287(3): 963-968
Hsieh, L.L.; Wainfan, E.; Hoshina, S.; Dizik, M.; Weinstein, I.B. 1989: Altered expression of retrovirus-like sequences and cellular oncogenes in mice fed methyl-deficient diets Cancer Research 49(14): 3795-3799
Bae, E.H.; Jung, Y.-T. 2011: Evaluation of the potential risk of porcine endogenous retrovirus (PERV) infection in nude mice Journal of Microbiology and Biotechnology 21(4): 387-390
Klinken, S.P.; Fredrickson, T.N.; Hartley, J.W.; Yetter, R.A.; Morse, H.C. 1988: Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS Journal of Immunology 140(4): 1123-1131