Detection of altered secondary lymphoid-tissue chemkine responsiveness in Balb/c mice infected with Schistosoma mansoni
Hassan, M.M.; Afify, H.; el-Dairouty, A.; Shalaby, M.; Assal, K.; Monib, M.El-Salahy.M.M.; el-Kadi, M.A.
Journal of the Egyptian Society of Parasitology 35(3): 1009-1017
2005
ISSN/ISBN: 1110-0583 PMID: 16333906 Document Number: 586645
To determine the extent to which Balb/c mice splenic T cells were affected by S. mansoni infection, this study aims to investigate the ability of the T cells to produce interferon (IFN)- alpha and their chemotactic ability at 7 weeks post-infection. The splenic T cells were capable of producing levels of IFN- alpha comparable with splenic T cells from naive mice. However, the T cells exhibited altered chemotactic activity, as evidenced by an inability to respond to secondary lymphoid-tissue chemokine (SLC/CCL21). Although no difference in chemokine expression was found between the spleens of infected versus control mice, chemokine production was greater in the livers of infected versus control mice. Collectively, these data indicate that Balb/c mice with 7-wk S. mansoni infection possess splenic T cells with altered chemotactic activity and that the alterations may be a consequence of granulomatous response in the liver.