A comparative study of antistroke activity of the new drug "cerebral" and its fractions in rats
Makarenko, A.N.; Kositsin, N.S.; Nazimov, I.V.; Svinov, M.M.; Goloborod'ko, E.V.; Pasikova, N.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 68(2): 15-20
2005
ISSN/ISBN: 0869-2092 PMID: 15934360 Document Number: 586644
The effect of the new drug "cerebral" and its fractions 1-3 on the model of bilateral hemorrhagic stroke in white rats was studied with reference to the action of cebrolysin and cerebrolysate-M. With respect to the general functional state, behavioral activity restoration, and morphological data, the most pronounced antistroke action was observed for the cerebral-1 fraction. This fraction was further separated into three subfractions. The most promising test results were obtained for the 1.2 subfraction, which was selected for the further investigation.