Functional activity of blood platelets during cerebral ischemia/reperfusion in rats
Vlasov, T.D.; Vivulanets, E.V.; Mindukshev, I.V.; Petrishchev, N.N.; Tvereva, E.K.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(4): 422-426
2000
ISSN/ISBN: 0869-8139 PMID: 10870217 Document Number: 523800
In rats with an incomplete brain ischemia and subsequent reperfusion, the platelets sensitivity to the ADP decreased more obviously during the postischemic reperfusion. The platelets seem to be transformed into a refraction state after their activation in brain ischemia. The platelets refraction state might depend on a secondary activation of the nitric oxide-synthase in the platelets.
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